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Overview of Complex Trait Genetics
Some challenges
Some challenges - continued
Slide 6
Genetic Association Studies: Family-Based vs. Case-Control vs. Population-Based
Phenotype-genotype association
Linkage Analysis
Linkage vs. Association Analysis
Genetic Architecture and Mapping Strategy
Complex Disease Genetic Architecture: Study Design Issues
Phenotype Issues in Complex Disease Genetics
Case-Control Association Study of COPD: TNFA -308 SNP (Huang, Su, and Chang, 1997)
Slide 15
Slide 16
Genotypes in Genetic Epidemiology
Haplotypes in Gene Localization
Reduction of Ancestral Haplotype Across Generations
Haplotype Determination Options
Analytical Issues in Genetic Association Studies
Unit of Analysis in Genetic Association Studies
Single-marker Logistic Regression
Data Manipulation in Genetic Association Studies
Statistical Testing in Genetic Association Studies
Determination of Effect Size in Genetic Association Studies
Slide 28
Case-Control Association Studies in COPD: Potential Causes of Inconsistent Results
Population Stratification
Association Between Diabetes Mellitus and Haplotype Gm 3;5,13,14 among Residents of Gila River Indian Community (Knowler et al. 1988)
Slide 32
Population Stratification in Genetic Association Studies
Multiple testing
Case-Control vs. TDT: Sample Size for Genome-wide Association Studies (McGinnis et al., Behav Genet 2002; 32:135)
Case-Control vs. TDT: Mode of Inheritance and Sample Size (McGinnis et al., Behav Genet 2002; 32:135)
Power Considerations in Case-Control vs. TDT Association Analysis
Slide 38
Slide 39
Author: Edwin K. Silverman, M.D., Ph.D.
E-mail:
Homepage: http://innateimmunity.net/
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